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Abstract

Colorectal cancer (CRC) is a malignancy that occurs in the colon, or large intestine. About 1.8 million people are diagnosed with CRC globally each year, and of that cohort only 65% will survive, making it the second deadliest cancer worldwide. High red meat consumption has been linked to molecular mechanisms that can lead to carcinogenesis. However, there is little research investigating red meat’s possible role in CRC progression, specifically metastasis. Due to the lack of research into red meat’s role in metastasis, the goal of the investigative portion of this study is to determine the effect of lean and fatty portions of raw red beef on human colorectal adenocarcinoma cells. The study found differences in atypical morphology over time in cells treated with lean or fatty portions of the meat. There were differences in cell proliferation and viability. This study also researches disparities in CRC outcomes of patients with different socioeconomic statuses. Finally, this study suggests more research should be conducted on the correlation of diet, socioeconomic status and CRC outcomes.

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